LIPID NANOPARTICLES AND USES THEREOF

The present disclosure relates generally to lipid nanoparticles (LNPs) and compositions comprising the same, and their use in delivery of agents, such as nucleic acid-based therapeutics, in particular to transfection recalcitrant cells and/or to lung tissue. La présente invention concerne de manière...

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Bibliographische Detailangaben
Hauptverfasser:	LEWIN, Sharon Ruth, CEVAAL, Paula Maria, FAREH, Mohamed, MOSO, Michael Aaron, DE ROSE, Robert, ZHAO, Wei, TRAPANI, Joseph, ROCHE, Michael John, KAN, Stanislav, FISHER, Bridget Molly
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present disclosure relates generally to lipid nanoparticles (LNPs) and compositions comprising the same, and their use in delivery of agents, such as nucleic acid-based therapeutics, in particular to transfection recalcitrant cells and/or to lung tissue. La présente invention concerne de manière générale des nanoparticules lipidiques (NPL) et des compositions les comprenant, ainsi que leur utilisation dans l'administration d'agents, tels que des agents thérapeutiques à base d'acide nucléique, en particulier dans des cellules réfractaires à la transfection et/ou dans le tissu pulmonaire.