LIPIDS FOR USE IN LIPID NANOPARTICLE FORMULATIONS

Compounds are provided having the following Structure (I) or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, wherein R1, R1, L1, L2, L2a, L2b, and A are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agen...

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Bibliographische Detailangaben
Hauptverfasser:	ARNS, Stephen Paul, TAN, Jason Samuel, GATENYO, Julia
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	Compounds are provided having the following Structure (I) or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, wherein R1, R1, L1, L2, L2a, L2b, and A are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided. L'invention concerne des composés ayant la structure (I) suivante ou un sel, un tautomère ou un stéréoisomère pharmaceutiquement acceptable de ceux-ci, R1, R1, L1, L2, L2a, L2b et A étant tels que définis dans la description. L'invention concerne également l'utilisation des composés en tant que composant de formulations de nanoparticules lipidiques pour l'administration d'un agent thérapeutique, des compositions comprenant les composés et des procédés pour leur utilisation et leur préparation.