IBOGAINE AND NORIBOGAINE ANALOGS AND METHODS OF USE

IBOGAINE AND NORIBOGAINE ANALOGS AND METHODS OF USE

Provided herein are compounds of Formula (I), (II), (III), or pharmaceutically acceptable salt, prodrug, or steroisomer thereof, and compositions thereof, wherein R1, R1', R2, R2', R3, R6, R7, X1, X2, X3, X4, and Z are defined herein. The disclosed compounds are useful for treating various...

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Bibliographische Detailangaben
Hauptverfasser: KAUR, Harpreet, ALI, Ahmed Magdy, KHAN, Tanweer A, GIBBS, Alan C, SHORT, Glenn, PERNI, Robert B, O'MEARA, Jeffrey
Format: Patent
Sprache:eng ; fre
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Zusammenfassung:Provided herein are compounds of Formula (I), (II), (III), or pharmaceutically acceptable salt, prodrug, or steroisomer thereof, and compositions thereof, wherein R1, R1', R2, R2', R3, R6, R7, X1, X2, X3, X4, and Z are defined herein. The disclosed compounds are useful for treating various conditions, including alcoholism, substance abuse disorder, and opioid use disorder. L'invention concerne des composés de formule (I), (II), (III), ou un sel, un promédicament ou un stéréoisomère pharmaceutiquement acceptable de ceux-ci, et des compositions de ceux-ci, R1, R1', R2, R2', R3, R6, R7, X1, X2, X3, X4 et Z étant définis ici. Les composés de l'invention sont utiles pour traiter diverses affections, y compris l'alcoolisme, le trouble d'abus de substances et le trouble d'utilisation des opioïdes.