METHOD FOR PREPARING ANTIBODY-DRUG CONJUGATE WITH UNIFORM DAR AND INCLUDING MALEIMIDE-CONTAINING LINKER

The present invention relates to a method for preparing an antibody-drug conjugate including a maleimide unit-containing linker. By the preparation method of the present invention, an antibody-drug conjugate with a uniform DAR may be provided. La présente invention concerne un procédé de préparation...

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Bibliographische Detailangaben
Hauptverfasser:	JIN, Sung-Ha, JEONG, Jin-Hyun
Format:	Patent
Sprache:	eng ; fre ; kor
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to a method for preparing an antibody-drug conjugate including a maleimide unit-containing linker. By the preparation method of the present invention, an antibody-drug conjugate with a uniform DAR may be provided. La présente invention concerne un procédé de préparation d'un conjugué anticorps-médicament comprenant un lieur contenant une unité maléimide. le procédé de préparation de la présente invention permet d'obtenir un conjugué anticorps-médicament ayant un DAR uniforme. 본 발명은 말레이미드(Maleimide) 유닛을 포함하는 링커를 포함하는 항체-약물 중합체의 제조방법에 관한 것으로, 본 발명의 제조방법에 의할 때, 균일한 DAR을 갖는 항체-약물 중합체를 제공할 수 있다.