COMPOUND CONTAINING OXO-PYRIDO-ALIPHATIC RING OR ALIPHATIC HETEROCYCLIC STRUCTURE, AND MEDICAL USE THEREOF
The present invention belongs to the technical field of medicine. Provided is a compound containing an oxo-pyrido-aliphatic ring or an aliphatic heterocyclic structure as represented by formula I, wherein R2, R3, X1, X2, X3, X4, X5, Y1, Y2, A, o and n are as defined in the description. The compound...
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| creator | ZHANG, Dewei YU, Pan YANG, You SU, Zhonghai DU, Shuwen ZHU, Jun HE, Quanhong YANG, Hao YUE, Jingmei ZHOU, Libo YANG, Anle WANG, Zhenyu LI, Zerui ZOU, Lianxin |
| description | The present invention belongs to the technical field of medicine. Provided is a compound containing an oxo-pyrido-aliphatic ring or an aliphatic heterocyclic structure as represented by formula I, wherein R2, R3, X1, X2, X3, X4, X5, Y1, Y2, A, o and n are as defined in the description. The compound with the new structure provided in the present invention has excellent CGRP antagonistic activity, and has the potential to treat various CGRP-mediated diseases, especially migraines or neuropathic pain.
L'invention se rapporte au domaine technique de la médecine. L'invention concerne un composé contenant un cycle oxo-pyrido-aliphatique ou une structure hétérocyclique aliphatique tel que représenté par la formule I, dans laquelle R2, R3, X1, X2, X3, X4, X5, Y1, Y2, A, o et n sont tels que définis dans la description. Le composé ayant la nouvelle structure selon la présente invention a une excellente activité antagoniste de CGRP, et a le potentiel de traiter diverses maladies médiées par CGRP, en particulier les mig |
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L'invention se rapporte au domaine technique de la médecine. L'invention concerne un composé contenant un cycle oxo-pyrido-aliphatique ou une structure hétérocyclique aliphatique tel que représenté par la formule I, dans laquelle R2, R3, X1, X2, X3, X4, X5, Y1, Y2, A, o et n sont tels que définis dans la description. Le composé ayant la nouvelle structure selon la présente invention a une excellente activité antagoniste de CGRP, et a le potentiel de traiter diverses maladies médiées par CGRP, en particulier les mig</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2024</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjLEKwkAQRNNYiPoPB7YG9LSI5bHZeAfxNmz20FQhyFmIaCD-PwYRbK2GefOYaXIDOlYUfK6AvBjnnT8oOlNaNexySk3pKmvEgeLPwupHLAoyQQPlWGrhABIYV8qMb0fMHZhShRqVWGSkYp5Mrt19iItvzpJlgQI2jf2zjUPfXeIjvtoT6bXeaa2zbG822_-sN4z4N0s</recordid><startdate>20241031</startdate><enddate>20241031</enddate><creator>ZHANG, Dewei</creator><creator>YU, Pan</creator><creator>YANG, You</creator><creator>SU, Zhonghai</creator><creator>DU, Shuwen</creator><creator>ZHU, Jun</creator><creator>HE, Quanhong</creator><creator>YANG, Hao</creator><creator>YUE, Jingmei</creator><creator>ZHOU, Libo</creator><creator>YANG, Anle</creator><creator>WANG, Zhenyu</creator><creator>LI, Zerui</creator><creator>ZOU, Lianxin</creator><scope>EVB</scope></search><sort><creationdate>20241031</creationdate><title>COMPOUND CONTAINING OXO-PYRIDO-ALIPHATIC RING OR ALIPHATIC HETEROCYCLIC STRUCTURE, AND MEDICAL USE THEREOF</title><author>ZHANG, Dewei ; YU, Pan ; YANG, You ; SU, Zhonghai ; DU, Shuwen ; ZHU, Jun ; HE, Quanhong ; YANG, Hao ; YUE, Jingmei ; ZHOU, Libo ; YANG, Anle ; WANG, Zhenyu ; LI, Zerui ; ZOU, Lianxin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2024222889A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng ; fre</language><creationdate>2024</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>ZHANG, Dewei</creatorcontrib><creatorcontrib>YU, Pan</creatorcontrib><creatorcontrib>YANG, You</creatorcontrib><creatorcontrib>SU, Zhonghai</creatorcontrib><creatorcontrib>DU, Shuwen</creatorcontrib><creatorcontrib>ZHU, Jun</creatorcontrib><creatorcontrib>HE, Quanhong</creatorcontrib><creatorcontrib>YANG, Hao</creatorcontrib><creatorcontrib>YUE, Jingmei</creatorcontrib><creatorcontrib>ZHOU, Libo</creatorcontrib><creatorcontrib>YANG, Anle</creatorcontrib><creatorcontrib>WANG, Zhenyu</creatorcontrib><creatorcontrib>LI, Zerui</creatorcontrib><creatorcontrib>ZOU, Lianxin</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>ZHANG, Dewei</au><au>YU, Pan</au><au>YANG, You</au><au>SU, Zhonghai</au><au>DU, Shuwen</au><au>ZHU, Jun</au><au>HE, Quanhong</au><au>YANG, Hao</au><au>YUE, Jingmei</au><au>ZHOU, Libo</au><au>YANG, Anle</au><au>WANG, Zhenyu</au><au>LI, Zerui</au><au>ZOU, Lianxin</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>COMPOUND CONTAINING OXO-PYRIDO-ALIPHATIC RING OR ALIPHATIC HETEROCYCLIC STRUCTURE, AND MEDICAL USE THEREOF</title><date>2024-10-31</date><risdate>2024</risdate><abstract>The present invention belongs to the technical field of medicine. Provided is a compound containing an oxo-pyrido-aliphatic ring or an aliphatic heterocyclic structure as represented by formula I, wherein R2, R3, X1, X2, X3, X4, X5, Y1, Y2, A, o and n are as defined in the description. The compound with the new structure provided in the present invention has excellent CGRP antagonistic activity, and has the potential to treat various CGRP-mediated diseases, especially migraines or neuropathic pain.
L'invention se rapporte au domaine technique de la médecine. L'invention concerne un composé contenant un cycle oxo-pyrido-aliphatique ou une structure hétérocyclique aliphatique tel que représenté par la formule I, dans laquelle R2, R3, X1, X2, X3, X4, X5, Y1, Y2, A, o et n sont tels que définis dans la description. Le composé ayant la nouvelle structure selon la présente invention a une excellente activité antagoniste de CGRP, et a le potentiel de traiter diverses maladies médiées par CGRP, en particulier les mig</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | COMPOUND CONTAINING OXO-PYRIDO-ALIPHATIC RING OR ALIPHATIC HETEROCYCLIC STRUCTURE, AND MEDICAL USE THEREOF |
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