COMPOUND CONTAINING OXO-PYRIDO-ALIPHATIC RING OR ALIPHATIC HETEROCYCLIC STRUCTURE, AND MEDICAL USE THEREOF

The present invention belongs to the technical field of medicine. Provided is a compound containing an oxo-pyrido-aliphatic ring or an aliphatic heterocyclic structure as represented by formula I, wherein R2, R3, X1, X2, X3, X4, X5, Y1, Y2, A, o and n are as defined in the description. The compound...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	ZHANG, Dewei, YU, Pan, YANG, You, SU, Zhonghai, DU, Shuwen, ZHU, Jun, HE, Quanhong, YANG, Hao, YUE, Jingmei, ZHOU, Libo, YANG, Anle, WANG, Zhenyu, LI, Zerui, ZOU, Lianxin
Format:	Patent
Sprache:	chi ; eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The present invention belongs to the technical field of medicine. Provided is a compound containing an oxo-pyrido-aliphatic ring or an aliphatic heterocyclic structure as represented by formula I, wherein R2, R3, X1, X2, X3, X4, X5, Y1, Y2, A, o and n are as defined in the description. The compound with the new structure provided in the present invention has excellent CGRP antagonistic activity, and has the potential to treat various CGRP-mediated diseases, especially migraines or neuropathic pain. L'invention se rapporte au domaine technique de la médecine. L'invention concerne un composé contenant un cycle oxo-pyrido-aliphatique ou une structure hétérocyclique aliphatique tel que représenté par la formule I, dans laquelle R2, R3, X1, X2, X3, X4, X5, Y1, Y2, A, o et n sont tels que définis dans la description. Le composé ayant la nouvelle structure selon la présente invention a une excellente activité antagoniste de CGRP, et a le potentiel de traiter diverses maladies médiées par CGRP, en particulier les mig