NON-METHYLATED CPG OLIGODEOXYNUCLEOTIDE AND APPLICATION THEREOF

The present invention provides a non-methylated cytosine-phosphate-guanine dinucleotide oligodeoxynucleotide and a B lymphocyte coupled thereto, the B lymphocyte can target and migrate to the diseased lymphoid organs and inhibit the B lymphocytes activated under pathological conditions, and has a ta...

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Bibliographische Detailangaben
Hauptverfasser:	HUANG, Tao, ZHU, Jianjun, WANG, Jishu, HU, Tanyu
Format:	Patent
Sprache:	chi ; eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention provides a non-methylated cytosine-phosphate-guanine dinucleotide oligodeoxynucleotide and a B lymphocyte coupled thereto, the B lymphocyte can target and migrate to the diseased lymphoid organs and inhibit the B lymphocytes activated under pathological conditions, and has a targeted therapeutic effect on pathological damage caused by B lymphocyte activation. La présente invention concerne un oligodésoxynucléotide dinucléotide cytosine-phosphate-guanine non méthylé et un lymphocyte B couplé à celui-ci, le lymphocyte B pouvant cibler et migrer vers les organes lymphoïdes malades et inhiber les lymphocytes B activés dans des conditions pathologiques, et ayant un effet thérapeutique ciblé sur un dommage pathologique provoqué par l'activation des lymphocytes B. 本发明提供了一种非甲基化的胞嘧啶-磷酸-鸟嘌呤二核苷酸的寡脱氧核苷酸以及与其偶联的B淋巴细胞，所述B淋巴细胞能够靶向游走到病变的淋巴器官中并抑制在病理条件下激活的B淋巴细胞，对于因B淋巴细胞激活造成的病理损伤具有靶向治疗作用。