PYRROLOPYRIDINE DERIVATIVES AS POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4

PYRROLOPYRIDINE DERIVATIVES AS POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4

6,7-Dihydrothiazolo[5,4-c]pyridines substituted in the 5-position with 6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-ones or furo[3,4-b]pyridin-5(7H)-ones are positive allosteric modulators of the muscarinic acetylcholine receptor M4 (mAChR M4) and may have use in treating neurological and psychiatric diso...

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Bibliographische Detailangaben
Hauptverfasser: ENGERS, Darren W, GREGRO, Alison R, TEMPLE, Kayla J, LONG, Madeline F, LINDSLEY, Craig W
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:6,7-Dihydrothiazolo[5,4-c]pyridines substituted in the 5-position with 6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-ones or furo[3,4-b]pyridin-5(7H)-ones are positive allosteric modulators of the muscarinic acetylcholine receptor M4 (mAChR M4) and may have use in treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction. Les 6,7-dihydrothiazolo [5,4-c] pyridines substituées en position 5 par 6,7-dihydro-5 H-pyrrolo [3,4-b] pyridin-5-ones ou furo [3,4-b] pyridin-5 (7H)-ones sont des modulateurs allostériques positifs du récepteur muscarinique de l'acétylcholine M4 (mAChR M4) et peuvent être utilisées dans le traitement de troubles neurologiques et psychiatriques associés à un dysfonctionnement du récepteur muscarinique de l'acétylcholine.