TREATMENT OF CANCER WITH A MEK KINASE INHIBITOR

Provided herein are compositions and methods for the treatment of cancer. Said compositions comprise a MEK kinase inhibitor that is 4-(dimethylphosphoryl)-N-(2-fluoro-4-iodophenyl)pyridin-3-amine (also known as KIN-7136). Some embodiments comprise combination therapy featuring the MEK kinase inhibit...

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Bibliographische Detailangaben
Hauptverfasser:	GRANDINETTI, Kathryn B, SURIBEN, Rowena, QUAH, Cheng, POWELL, Benjamin, WILLIAMS, Richard Thomas, COX, Jason M, KANIA, Robert S, MILLER, Nichol L.G
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Provided herein are compositions and methods for the treatment of cancer. Said compositions comprise a MEK kinase inhibitor that is 4-(dimethylphosphoryl)-N-(2-fluoro-4-iodophenyl)pyridin-3-amine (also known as KIN-7136). Some embodiments comprise combination therapy featuring the MEK kinase inhibitor with at least one additional oncology therapeutic agent. L'invention concerne des composés et des méthodes pour le traitement du cancer. Lesdites compositions comprennent un inhibiteur de MEK kinase qui est la 4-(diméthylphosphoryl)-N-(2-fluoro-4-iodophényl)pyridin-3-amine (également connue sous le nom de KIN-7136). Certains modes de réalisation comprennent une polythérapie comprenant l'inhibiteur de MEK kinase avec au moins un agent thérapeutique oncologique supplémentaire.