COMBINATION OF A MENIN-LL1 INHIBITOR, A DNA INTERCALATING AGENT AND A PYRIMIDINE ANALOGUE TO TREAT A HEMATOPOIETIC DISORDER

The present invention relates to combinations comprising a therapeutically effective amount of a menin-mixed-lineage leukemia 1 (menin-MLL) inhibitor; and a therapeutically effective amount of a DNA intercalating agent and a pyrimidine analog; as well as to methods for treating a subject diagnosed w...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	PACKMAN, Kathryn Elizabeth, BARREYRO, Laura, FERRANTE, Lucille Angela, GUTTKE, Christina Diane
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The present invention relates to combinations comprising a therapeutically effective amount of a menin-mixed-lineage leukemia 1 (menin-MLL) inhibitor; and a therapeutically effective amount of a DNA intercalating agent and a pyrimidine analog; as well as to methods for treating a subject diagnosed with cancer using such combinations. La présente invention concerne des combinaisons comprenant une quantité thérapeutiquement efficace d'un inhibiteur de la protéine 1 de la leucémie de lignée mixte ménine (ménine-MLL); et une quantité thérapeutiquement efficace d'un agent intercalant de l'ADN et d'un analogue de pyrimidine; ainsi que des méthodes de traitement d'un sujet diagnostiqué avec un cancer à l'aide de telles combinaisons.