NOVEL COMPOUNDS AS α4β7 INHIBITORS

Novel compounds that act as inhibitors of α4β7 integrins are disclosed. Pharmaceutical compositions and methods of use for inhibitors of α4β7 integrins are disclosed. In particular, methods of using the α4β7 inhibtors in the treatment of diseases or conditions associated to inflammatory bowel diseas...

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Hauptverfasser: RUDA, Gian Filippo, MIDUTURU, Chandrasekhar Venkataraman, BISSARO, Maicol, SABBAH, Mohamad
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creator RUDA, Gian Filippo
MIDUTURU, Chandrasekhar Venkataraman
BISSARO, Maicol
SABBAH, Mohamad
description Novel compounds that act as inhibitors of α4β7 integrins are disclosed. Pharmaceutical compositions and methods of use for inhibitors of α4β7 integrins are disclosed. In particular, methods of using the α4β7 inhibtors in the treatment of diseases or conditions associated to inflammatory bowel diseases including ulcerative colitis and Crohn's disease. L'invention concerne de nouveaux composés qui agissent en tant qu'inhibiteurs d'intégrines α4β7. L'invention concerne également des compositions pharmaceutiques et des procédés d'utilisation pour des inhibiteurs d'intégrines α4β7. En particulier, l'invention concerne des procédés d'utilisation des inhibiteurs d'α4β7 dans le traitement de maladies ou d'affections associées à des maladies intestinales inflammatoires comprenant la rectocolite hémorragique et la maladie de Crohn.
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subjects ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title NOVEL COMPOUNDS AS α4β7 INHIBITORS
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