NOVEL COMPOUNDS AS α4β7 INHIBITORS

Novel compounds that act as inhibitors of α4β7 integrins are disclosed. Pharmaceutical compositions and methods of use for inhibitors of α4β7 integrins are disclosed. In particular, methods of using the α4β7 inhibtors in the treatment of diseases or conditions associated to inflammatory bowel diseas...

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Bibliographische Detailangaben
Hauptverfasser:	RUDA, Gian Filippo, MIDUTURU, Chandrasekhar Venkataraman, BISSARO, Maicol, SABBAH, Mohamad
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Novel compounds that act as inhibitors of α4β7 integrins are disclosed. Pharmaceutical compositions and methods of use for inhibitors of α4β7 integrins are disclosed. In particular, methods of using the α4β7 inhibtors in the treatment of diseases or conditions associated to inflammatory bowel diseases including ulcerative colitis and Crohn's disease. L'invention concerne de nouveaux composés qui agissent en tant qu'inhibiteurs d'intégrines α4β7. L'invention concerne également des compositions pharmaceutiques et des procédés d'utilisation pour des inhibiteurs d'intégrines α4β7. En particulier, l'invention concerne des procédés d'utilisation des inhibiteurs d'α4β7 dans le traitement de maladies ou d'affections associées à des maladies intestinales inflammatoires comprenant la rectocolite hémorragique et la maladie de Crohn.