DIARYLACETYLENE COMPOUND, PREPARATION METHOD THEREFOR, AND USE THEREOF

The present invention provides a diarylacetylene compound, a preparation method therefor, and a use thereof. A bioactive isoindolinyl-piperazinyl urea parent nucleus group comprised in the diarylacetylene compound is further chemically modified to generate a plurality of higher bioactive compounds or pharmaceutically acceptable salts, hydrates, solvates, metabolites, prodrugs or pharmaceutical compositions thereof, thereby expanding the wide application of the compounds in biomedicine and the development prospects of pharmaceutical preparations. The compound can target STAT3 proteins, can significantly inhibit the proliferation of various tumor cells such as lung cancer cells, breast cancer cells, liver cancer cells, pancreatic cancer cells and gastric cancer cells at a low dose (nanomole), and can effectively inhibit the growth of xenograft tumors in mice, indicating that the compound has the prospects of being developed into drugs for preventing and/or treating tumors and other diseases related to abnormal