N2-((5-HYDROXY)-2-PYRIDYL)-PYRIDINE-2,4-DIAMINE DERIVATIVES AS EHMT1/2 MODULATORS FOR THE TREATMENT OF CANCER

The present invention relates to N2-((5-hydroxy)-2-pyridyl)- pyridine-2,4-diamine derivatives of formula (I) as EHMT1 or EHMT2 modulators for use in methods of treatment of cancer, sickle cell disease, and beta thalassemia. Preferred compounds of the compounds of formula (I) are e.g. 2,3- dihydro-[l...

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Bibliographische Detailangaben
Hauptverfasser:	COME, Jon H, THRONER, Scott, MAXWELL, John P, WILLIAMS, Brett, VACCA, Joseph P
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to N2-((5-hydroxy)-2-pyridyl)- pyridine-2,4-diamine derivatives of formula (I) as EHMT1 or EHMT2 modulators for use in methods of treatment of cancer, sickle cell disease, and beta thalassemia. Preferred compounds of the compounds of formula (I) are e.g. 2,3- dihydro-[l,4]dioxino[2,3-b]pyridine derivatives, 2,3-dihydrofuro[3,2- b]pyridine derivatives, 3,4-dihydro-2H-pyrano[3,2-b]pyridine derivatives, and [l,3]dioxolo[4,5-b]pyridine derivatives. La présente invention concerne des dérivés de N2-((5-hydroxy)-2-pyridyl)-pyridine-2,4-diamine de formule (I), utilisés comme modulateurs d'EHMT1 ou d'EHMT2, destinés à être utilisés dans des méthodes de traitement du cancer, de la drépanocytose et de la bêta-thalassémie. Les composés préférés des composés de formule (I) sont, par exemple, des dérivés de 2,3-dihydro-[l,4]dioxino[2,3-b]pyridine, des dérivés de 2,3-dihydrofuro[3,2-b]pyridine, des dérivés de 3,4-dihydro-2H-pyrano[3,2-b]pyridine, et des dérivés de [l, 3]dioxolo[4,5-b]pyridine.