NOVEL SUBSTITUTED PYRROLE COMPOUNDS, COMPOSITIONS COMPRISING THE SUBSTITUTED PYRROLE COMPOUND, AND METHODS OF USE THEREOF

NOVEL SUBSTITUTED PYRROLE COMPOUNDS, COMPOSITIONS COMPRISING THE SUBSTITUTED PYRROLE COMPOUND, AND METHODS OF USE THEREOF

The present disclosure provides novel substituted pyrrole compounds that can serve as inhibitors of lactate dehydrogenase A, pharmaceutical compositions, comprising at least one of such novel substituted pyrrole compounds, and methods of using at least one of such compounds or compositions in treati...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: XU, Ke, HANING, Helmut, ZHOU, Shiqiang, XUN, Guoliang, XIANYU, AnJin
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The present disclosure provides novel substituted pyrrole compounds that can serve as inhibitors of lactate dehydrogenase A, pharmaceutical compositions, comprising at least one of such novel substituted pyrrole compounds, and methods of using at least one of such compounds or compositions in treating or preventing diseases associated with lactate dehydrogenase A activities,such as cancers. La présente invention concerne de nouveaux composés de pyrrole substitués qui peuvent servir d'inhibiteurs de lactate déshydrogénase A, des compositions pharmaceutiques, comprenant au moins l'un de ces nouveaux composés de pyrrole substitués, et des procédés d'utilisation d'au moins l'un de tels composés ou compositions dans le traitement ou la prévention de maladies associées à des activités de la lactate déshydrogénase A, telles que des cancers.