SEMI-SATURATED BICYCLIC DERIVATIVES AND RELATED USES

The present disclosure relates to compounds of Formula (I): and to their prodrugs, pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein are useful for modulating DNA polymerase Θ activity and may be used in...

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Bibliographische Detailangaben
Hauptverfasser:	REUTERSHAN, Michael H, WANG, Haoxuan, MCGOWAN, Meredeth A, SCHENKEL, Laurie B, BUTLER, John R, GAO, Cen, BAI, Yonghong, GUZI, Timothy J
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present disclosure relates to compounds of Formula (I): and to their prodrugs, pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein are useful for modulating DNA polymerase Θ activity and may be used in the treatment of disorders in which DNA polymerase Θ activity is implicated, such as cancer. La présente invention concerne des composés de formule (I) : et leurs promédicaments, des sels pharmaceutiquement acceptables, des compositions pharmaceutiques, des procédés d'utilisation et des procédés pour leur préparation. Les composés de l'invention sont utiles pour moduler l'activité de l'ADN polymérase thêta et peuvent être utilisés dans le traitement de troubles dans lesquels l'activité de l'ADN polymérase thêta est impliquée, tels que le cancer.