NITROGEN-CONTAINING HETEROCYCLIC COMPOUND AS AAK1 INHIBITOR

The present invention relates to a use of a nitrogen-containing heterocyclic compound for inhibiting the activity of an adapter protein-associated kinase 1 (AAK1 kinase) or a pharmaceutically acceptable salt thereof in drugs for treating or preventing diseases or disorders mediated by the activity o...

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Bibliographische Detailangaben
Hauptverfasser:	LU, Xin, ZHAO, Fang, YANG, Wei, YANG, Jiale, WANG, Zhi, YAO, Yueyue, LU, Pingbo
Format:	Patent
Sprache:	chi ; eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to a use of a nitrogen-containing heterocyclic compound for inhibiting the activity of an adapter protein-associated kinase 1 (AAK1 kinase) or a pharmaceutically acceptable salt thereof in drugs for treating or preventing diseases or disorders mediated by the activity of AAK1. Specifically, the present invention provides a compound represented by formula I, and a stereoisomer or pharmaceutically acceptable salt thereof, wherein the definition of each group is as described in the description. The compound has high AAK1 inhibitory activity. La présente invention concerne une utilisation d'un composé hétérocyclique contenant de l'azote pour inhiber l'activité de la kinase 1 associée à la protéine d'adaptateur (AAK1 kinase) ou d'un sel pharmaceutiquement acceptable de celle-ci dans des médicaments pour le traitement ou la prévention de maladies ou de troubles médiés par l'activité de AAK1. Plus particulièrement, la présente invention concerne un composé représenté par la formule I, e