ANTIBODY SPECIFICALLY TARGETING B7-H4, AND PREPARATION METHOD THEREFOR AND USE THEREOF

The present invention relates to an antibody specifically targeting B7-H4, and a preparation method therefor and the use thereof. In the present invention, the method comprises screening, on the basis of a phage display technique, an antibody variable region targeting B7-H4, then transforming same i...

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Bibliographische Detailangaben
Hauptverfasser:	WANG, Yang, ZHU, Yanyang, ZHANG, Qiuyu, ZHOU, Linlin, ZHANG, Renlu
Format:	Patent
Sprache:	chi ; eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to an antibody specifically targeting B7-H4, and a preparation method therefor and the use thereof. In the present invention, the method comprises screening, on the basis of a phage display technique, an antibody variable region targeting B7-H4, then transforming same into a full-length antibody, constructing an expression vector, performing eukaryotic expression and purification so as to obtain the antibody specifically targeting B7-H4. La présente invention concerne un anticorps ciblant de manière spécifique B7-H4, son procédé de préparation et son utilisation. Dans la présente invention, le procédé comprend le criblage, sur la base d'une technique d'affichage sur phage, d'une région variable d'anticorps ciblant B7-H4, puis la transformation de celui-ci en un anticorps pleine longueur, la construction d'un vecteur d'expression, la réalisation d'une expression et d'une purification eucaryotes de façon à obtenir l'anticorps ciblant de manière spécifique B7-H4. 本发明涉及特异性靶向B7-H4的抗体及