HEMOSTATIC SEALANT POWDER FOR SEALING LEAKS IN TISSUES

Disclosed herein are powdered compositions comprised of fibrinogen, thrombin, glycerol-water solution, and optionally oxidized cellulose (OC), wherein the glycerol is present at a concentration ranging from about 0.7% to about 6%, by weight; and wherein the OC is present at a concentration below abo...

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Bibliographische Detailangaben
Hauptverfasser:	LI, Yufu, DENG, Xueqin, CHEN, Shuang, WANG, Yaping, XIE, Tingwan, LI, Hai, ZHANG, Xuemei
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES DISINFECTION, STERILISATION, OR DEODORISATION OF AIR HUMAN NECESSITIES HYGIENE MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES MEDICAL OR VETERINARY SCIENCE METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	Disclosed herein are powdered compositions comprised of fibrinogen, thrombin, glycerol-water solution, and optionally oxidized cellulose (OC), wherein the glycerol is present at a concentration ranging from about 0.7% to about 6%, by weight; and wherein the OC is present at a concentration below about 9%, by weight, or is absent. Methods of making the compositions, and uses of the compositions in methods for treating a bleeding tissue, and for sealing leaks in tissues are further disclosed. L'invention concerne des compositions en poudre comprenant du fibrinogène, de la thrombine, une solution de glycérol-eau et éventuellement de la cellulose oxydée (OC), le glycérol étant présent à une concentration comprise entre environ 0,7 % et environ 6 % en poids ; et l'OC étant présente à une concentration inférieure à environ 9 %, en poids, ou étant absente. L'invention concerne en outre des procédés de fabrication des compositions, et des utilisations des compositions dans des procédés de traitement d'un tissu saignant, et de scellement de fuites dans des tissus.