FC FRAGMENTS THAT BIND FCRN AND METHODS OF USE

Described herein are Fc fragment variants that bind neonatal Fc receptor (FcRn) that effectively block IgG from binding to FcRn, and methods of use thereof. In certain aspects, described herein are methods of inhibiting FcRn biological activity. In certain aspects, described herein are pharmaceutica...

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Bibliographische Detailangaben
Hauptverfasser:	OH, Jason Z, SHAHEEN, Hussam H, VAZ, Rita L, LIU, Yuqi
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Described herein are Fc fragment variants that bind neonatal Fc receptor (FcRn) that effectively block IgG from binding to FcRn, and methods of use thereof. In certain aspects, described herein are methods of inhibiting FcRn biological activity. In certain aspects, described herein are pharmaceutical compositions comprising the Fc fragments. In certain aspects, the Fc fragments and methods described herein are used for treatment of a disease or disorder related to an antibody (e.g., an autoimmune disease or an unwanted side effect of a therapeutic antibody). L'invention concerne des variants de fragment Fc qui se lient au récepteur Fc néonatal (FcRn) qui bloquent efficacement l'IgG de la liaison au FcRn, et des procédés d'utilisation de ceux-ci. Dans certains aspects, l'invention concerne des procédés d'inhibition de l'activité biologique de FcRn. Dans certains aspects, l'invention concerne des compositions pharmaceutiques comprenant les fragments Fc. Dans certains aspects, les fragments Fc et les procédés décrits ici sont utilisés pour le traitement d'une maladie ou d'un trouble associé à un anticorps (par exemple, une maladie auto-immune ou un effet secondaire indésirable d'un anticorps thérapeutique).