NECTIN-4 BINDING AGENTS AND METHODS OF USE

NECTIN-4 BINDING AGENTS AND METHODS OF USE

Provided herein are Nectin-4 binding agents, multi-specific binding agents thereof, polynucleotides encoding the same, and compositions comprising the same. The present disclosure further provides methods of treating cancer in a subject in need thereof comprising administration of the Nectin-4 bindi...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: LUTJE HULSIK, David, VAN HELDEN, Paula Maria Wilhelmina, DE JONG, Milon, SALLER, Manfred, VAN DER VLIET, Johannes Jelle, ADANG, Anton Egbert Peter, ROOVERS, Robertus Cornelis
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:Provided herein are Nectin-4 binding agents, multi-specific binding agents thereof, polynucleotides encoding the same, and compositions comprising the same. The present disclosure further provides methods of treating cancer in a subject in need thereof comprising administration of the Nectin-4 binding agents and multi-specific binding agents comprising the same to a subject in need thereof. La présente invention concerne des agents de liaison à la nectine -4, des agents de liaison multi-spécifiques de ceux-ci, des polynucléotides codant pour ceux-ci, et des compositions les comprenant. La présente invention concerne en outre des méthodes de traitement du cancer chez un sujet dont l'état le nécessite, consistant en l'administration des agents de liaison à la nectine-4 et d'agents de liaison multi-spécifiques les comprenant à un sujet dont l'état le nécessite.