NOVEL PD-L1 INHIBITORS

The present invention relates to compounds for modulating PD-1/PD-L1 protein/protein interaction that are useful in the treatment of various diseases associated with over-expression of PD-1/PD-L1, including infectious diseases and cancer. The invention additionally relates to compositions comprising...

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Bibliographische Detailangaben
Hauptverfasser:	BERGES, Maria Isabel, ALMANSA ROSALES, Carmen, BASU, Sujay
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to compounds for modulating PD-1/PD-L1 protein/protein interaction that are useful in the treatment of various diseases associated with over-expression of PD-1/PD-L1, including infectious diseases and cancer. The invention additionally relates to compositions comprising such compounds as well as to their uses. La présente invention concerne des composés pour moduler l'interaction protéine/protéine PD-1/PD-L1 qui sont utiles dans le traitement de diverses maladies associées à la surexpression de PD-1/PD-L1, y compris des maladies infectieuses et le cancer. L'invention concerne en outre des compositions comprenant de tels composés ainsi que leurs utilisations.