PEG TARGETING COMPOUNDS FOR DELIVERY OF THERAPEUTICS

Provided herein are targeting compounds (e.g., a compound of Formula I, a stereoisomer thereof, a tautomer thereof, and/or a pharmaceutically acceptable salt thereof), lipid nanoparticle (LNP) compositions comprising such targeting compounds and the use thereof. The LNP compositions described herein...

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Hauptverfasser: KIM, Junyong, SUR, Sreyoshi, SEEPERSAUD, Mohindra, KUMARASINGHE, Ellalahewage Sathyajith
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creator KIM, Junyong
SUR, Sreyoshi
SEEPERSAUD, Mohindra
KUMARASINGHE, Ellalahewage Sathyajith
description Provided herein are targeting compounds (e.g., a compound of Formula I, a stereoisomer thereof, a tautomer thereof, and/or a pharmaceutically acceptable salt thereof), lipid nanoparticle (LNP) compositions comprising such targeting compounds and the use thereof. The LNP compositions described herein may further comprise one or more selected from ionizable lipids, PEG-lipids, phospholipids, and structural lipids. L'invention concerne des composés de ciblage (par exemple, un composé de formule I, un stéréoisomère de celui-ci, un tautomère de celui-ci, et/ou un sel pharmaceutiquement acceptable de celui-ci), des compositions de nanoparticules lipidiques (LNP) comprenant de tels composés de ciblage et leur utilisation. Les compositions de LNP décrites ici peuvent en outre comprendre un ou plusieurs lipides ionisables, des lipides PEG, des phospholipides et des lipides structuraux.
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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title PEG TARGETING COMPOUNDS FOR DELIVERY OF THERAPEUTICS
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