PEG TARGETING COMPOUNDS FOR DELIVERY OF THERAPEUTICS

Provided herein are targeting compounds (e.g., a compound of Formula I, a stereoisomer thereof, a tautomer thereof, and/or a pharmaceutically acceptable salt thereof), lipid nanoparticle (LNP) compositions comprising such targeting compounds and the use thereof. The LNP compositions described herein...

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Bibliographische Detailangaben
Hauptverfasser:	KIM, Junyong, SUR, Sreyoshi, SEEPERSAUD, Mohindra, KUMARASINGHE, Ellalahewage Sathyajith
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Provided herein are targeting compounds (e.g., a compound of Formula I, a stereoisomer thereof, a tautomer thereof, and/or a pharmaceutically acceptable salt thereof), lipid nanoparticle (LNP) compositions comprising such targeting compounds and the use thereof. The LNP compositions described herein may further comprise one or more selected from ionizable lipids, PEG-lipids, phospholipids, and structural lipids. L'invention concerne des composés de ciblage (par exemple, un composé de formule I, un stéréoisomère de celui-ci, un tautomère de celui-ci, et/ou un sel pharmaceutiquement acceptable de celui-ci), des compositions de nanoparticules lipidiques (LNP) comprenant de tels composés de ciblage et leur utilisation. Les compositions de LNP décrites ici peuvent en outre comprendre un ou plusieurs lipides ionisables, des lipides PEG, des phospholipides et des lipides structuraux.