TRANS-CYCLOOCTENE WITH IMPROVED T-LINKER

Disclosed herein include trans-cyclooctenes (TCOs) that may have improved properties, for example in clinical use. In certain embodiments, the TCOs may have improved in vitro and in vivo properties as compared to other TCOs. The disclosure also pertains to in vivo and in vitro methods of using said...

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Bibliographische Detailangaben
Hauptverfasser:	VERSTEEGEN, Ronny Mathieu, ROSSIN, Raffaella, KLEIJN, Laurens Henri Johan, ROBILLARD, Marc Stefan
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Disclosed herein include trans-cyclooctenes (TCOs) that may have improved properties, for example in clinical use. In certain embodiments, the TCOs may have improved in vitro and in vivo properties as compared to other TCOs. The disclosure also pertains to in vivo and in vitro methods of using said trans-cyclooctenes, as well as medical uses thereof, methods for making said TCOs, and compositions and/or combinations comprising said TCOs. L'invention concerne des trans -cyclooctènes (TCO) qui peuvent avoir des propriétés améliorées, par exemple en utilisation clinique. Dans certains modes de réalisation, les TCO peuvent avoir des propriétés in vitro et in vivo améliorées en comparaison avec d'autres TCO. L'invention concerne également des procédés in vivo et in vitro d'utilisation desdits trans-cyclooctènes, ainsi que leurs utilisations médicales, des procédés de fabrication desdits TCO, et des compositions et/ou des combinaisons comprenant lesdits TCO.