SELF-ASSEMBLED NANOPARTICLES COMPRISING GLYCOCHOLIC ACID-POLYMER CONJUGATE, METHOD FOR PRODUCING SAME, AND DRUG DELIVERY COMPOSITION COMPRISING SAME

SELF-ASSEMBLED NANOPARTICLES COMPRISING GLYCOCHOLIC ACID-POLYMER CONJUGATE, METHOD FOR PRODUCING SAME, AND DRUG DELIVERY COMPOSITION COMPRISING SAME

The present invention relates to self-assembled nanoparticles comprising a glycocholic acid-polymer conjugate, a method for producing same, and a drug delivery composition comprising same as an active ingredient. The self-assembled nanoparticles include a glycocholic acid-polymer conjugate and an an...

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Hauptverfasser: CHO, Hana, HYUN, Joo Hee, KANG, Han Chang
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Sprache:eng ; fre ; kor
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HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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HYUN, Joo Hee
KANG, Han Chang
description The present invention relates to self-assembled nanoparticles comprising a glycocholic acid-polymer conjugate, a method for producing same, and a drug delivery composition comprising same as an active ingredient. The self-assembled nanoparticles include a glycocholic acid-polymer conjugate and an anticancer agent, and glycocholic acid exists on the surface of the nanoparticles so that particle stability is maintained in the gastrointestinal environment, and is absorbed in a stable state so as to be distributed to various organs. La présente invention se rapporte à des nanoparticules auto-assemblées comprenant un conjugué acide glycocholique-polymère, à leur procédé de production et à une composition d'administration de médicament les comprenant en tant que principe actif. Les nanoparticules auto-assemblées comprennent un conjugué acide glycocholique-polymère et un agent anticancéreux et de l'acide glycocholique existe sur la surface des nanoparticules de telle sorte que la stabilité des particules soit maintenue dans l'environnement gastro-intestinal, et soit absorbée dans un état stable de façon à être distribuée à divers organes. 본 발명은 글리코콜산-고분자 접합체를 포함하는 자기조립 나노입자, 이의 제조방법 및 이를 유효성분으로 포함하는 약물전달용 조성물에 관한 것으로, 상기 자기조립 나노입자는 글리코콜산-고분자의 접합체 및 항암제를 포함하고 나노입자 표면에 글리코콜산이 존재하여 위장 환경에서 입자안정성이 유지되고, 안정한 상태에서 흡수되어 여러 장기로 분포되는 이점이 있다.
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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title SELF-ASSEMBLED NANOPARTICLES COMPRISING GLYCOCHOLIC ACID-POLYMER CONJUGATE, METHOD FOR PRODUCING SAME, AND DRUG DELIVERY COMPOSITION COMPRISING SAME
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