THERAPEUTIC T CELL RECEPTORS TARGETING KRAS G12D

THERAPEUTIC T CELL RECEPTORS TARGETING KRAS G12D

Disclosed herein are therapeutic T cell receptors (TCRs) that bind to a KRAS G12D neoantigen, engineered cells expressing such TCRs, pharmaceutical compositions comprising such cells, and methods of treatment using such cells or pharmaceutical compositions. L'invention concerne des récepteurs d...

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Bibliographische Detailangaben
Hauptverfasser: YANG, Rena Whei-Ming, YUSKO, Erik, KLINGER, Mark, OH, Soyoung, EBERT, Peter, RUTZ, Sascha, SENGER, Kate Halliwell
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:Disclosed herein are therapeutic T cell receptors (TCRs) that bind to a KRAS G12D neoantigen, engineered cells expressing such TCRs, pharmaceutical compositions comprising such cells, and methods of treatment using such cells or pharmaceutical compositions. L'invention concerne des récepteurs de lymphocytes T thérapeutiques (TCR) qui se lient à un néo-antigène KRAS G12D, des cellules modifiées exprimant de tels TCR, des compositions pharmaceutiques comprenant de telles cellules, et des méthodes de traitement utilisant de telles cellules ou compositions pharmaceutiques.