[1,3]THIAZOLO[4,5-D]-PYRIMIDIN-7-ONES AS INHIBITORS OF NOX4

[1,3]THIAZOLO[4,5-D]-PYRIMIDIN-7-ONES AS INHIBITORS OF NOX4

The present disclosure provides [1,3]thiazolo[4,5-d]-pyrimidin-7-ones that are inhibitors of NOX4, and are therefore useful for the treatment of diseases treatable by inhibition of NOX4. Also provided are pharmaceutical compositions containing the same, and processes for preparing said compounds. La...

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Bibliographische Detailangaben
Hauptverfasser: BAUSCHATZ, Elmar, GODBOUT, Cédrickx, HOENKE, Christoph, KUTTRUFF, Christian Andreas, BUETTNER, Frank, WIEDENMAYER, Dieter, HEIMANN, Annekatrin Charlotte, KONTES, Ferenc, WILDERMUTH, Raphael, GNAMM, Christian
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:The present disclosure provides [1,3]thiazolo[4,5-d]-pyrimidin-7-ones that are inhibitors of NOX4, and are therefore useful for the treatment of diseases treatable by inhibition of NOX4. Also provided are pharmaceutical compositions containing the same, and processes for preparing said compounds. La présente invention concerne des [1,3]thiazolo[4,5-d]-pyrimidon-7-ones qui sont des inhibiteurs de NOX4, et sont par conséquent utiles pour le traitement de maladies pouvant être traitées par inhibition de NOX4. L'invention concerne également des compositions pharmaceutiques les contenant, et des procédés de préparation desdits composés.