HETEROARYL-SUBSTITUTED PYRAZOLO/IMIDAZO PYRIDINE COMPOUNDS

Provided herein are compounds having the formula: (I) or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, Ar, X1, X2, LB and ring B have the meanings as provided herein. The provided compounds are useful Poly ADP-ribose glycohydrolase (PARG) inhibitors. L'invention co...

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Bibliographische Detailangaben
Hauptverfasser:	JONES, Brian T, TAYGERLY, Joshua P. G, RYAN, Jonathon, XU, Ying-zi, FLEURY, Melissa, MATIER, Carson Douglas, ALBERS, Aaron Edward, BARSANTI, Paul A
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Provided herein are compounds having the formula: (I) or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, Ar, X1, X2, LB and ring B have the meanings as provided herein. The provided compounds are useful Poly ADP-ribose glycohydrolase (PARG) inhibitors. L'invention concerne des composés ayant la formule : (I) ou un sel pharmaceutiquement acceptable de celui-ci, où R1, R2, R3, R4, R5, R6, Ar, X1, X2, LB et le cycle B ont les significations telles que fournies ici. Les composés selon l'invention sont des inhibiteurs de la poly ADP-ribose glycohydrolase (PARG) utiles.