CYCLIN DEPENDENT KINASE DEGRADERS AND METHODS OF USE THEREOF

The present disclosure relates to novel compounds and pharmaceutical compositions thereof, and methods for degrading CDK2 and/or CCNE1 with the compounds and compositions of the disclosure. The present disclosure further relates to, but is not limited to, methods for treating disorders associated wi...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: ALLEN, Bryce K, DWIGHT, Timothy A
Format: Patent
Sprache:eng ; fre
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Beschreibung
Zusammenfassung:The present disclosure relates to novel compounds and pharmaceutical compositions thereof, and methods for degrading CDK2 and/or CCNE1 with the compounds and compositions of the disclosure. The present disclosure further relates to, but is not limited to, methods for treating disorders associated with CDK2 and/or CCNE1 with the compounds and compositions of the disclosure. La présente invention concerne de nouveaux composés et des compositions pharmaceutiques associées, et des procédés de dégradation de CDK2 et/ou CCNE1 avec les composés et les compositions de l'invention. La présente invention concerne en outre, mais de façon non limitative, des procédés de traitement de troubles associés à CDK2 et/ou à CCNE1 avec les composés et les compositions de l'invention.