SUBSTITUTED PYRAZOLO-PYRIMIDINES AND USES THEREOF

The present disclosure provides modified forms, or prodrugs, of therapeutic agents or compounds that are inhibitors of PIKfyve kinases useful for the treatment of neurological diseases treatable by inhibition of PIKfyve. Also provided are pharmaceutical compositions containing such prodrug compounds...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	KOPEC, Brian, SHOOK, Brian C, GALEMMO, JR, LIANG, Weiling, CHOI-MUCKERHEIDE, Irene Y
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present disclosure provides modified forms, or prodrugs, of therapeutic agents or compounds that are inhibitors of PIKfyve kinases useful for the treatment of neurological diseases treatable by inhibition of PIKfyve. Also provided are pharmaceutical compositions containing such prodrug compounds, and methods of treatment using such compounds. La présente invention concerne des formes modifiées, ou des promédicaments, d'agents thérapeutiques ou de composés qui sont des inhibiteurs de kinases PIKfyve utiles pour le traitement de maladies neurologiques pouvant être traitées par inhibition de PIKfyve. L'invention concerne également des compositions pharmaceutiques contenant de tels composés de promédicament, et des procédés de traitement faisant appel à de tels composés.