PHARMACEUTICAL COMPOSITION FOR PREVENTION OR TREATMENT OF AGE-RELATED MUSCULOSKELETAL DISORDERS

The present invention relates to a composition for the prevention, amelioration or treatment of age-related musculoskeletal disorders, the composition comprising a lysosomal ABCA1 inhibitor. More particularly, the composition of the present invention inhibits the transport of cellular ABCA1 to lysosomes or inhibits ABCA1 in lysosomes, by comprising the lysosomal ABCA1 inhibitor, and thus inhibits lysosomal cholesterol accumulation and the production of senescence-associated inflammatory factor (SASP). Therefore, the composition can inhibit age-related inflammation, and prevent, ameliorate or treat age-related musculoskeletal disorders. La présente invention concerne une composition pour la prévention, l'atténuation ou le traitement des troubles musculo-squelettiques liés à l'âge, la composition comprenant un inhibiteur de l'ABCA1 lysosomal. Plus particulièrement, la composition de la présente invention inhibe le transport de l'ABCA1 cellulaire vers les lysosomes ou inhibe l'ABCA1 dans les lysosomes, en comprenant l'inhibiteur de l'ABCA1 lysosomal, et inhibe ainsi l'accumulation du cholestérol lysosomal et la production du facteur inflammatoire associé à la sénescence (SASP). Par conséquent, la composition peut inhiber une inflammation liée à l'âge et prévenir, atténuer ou traiter les troubles musculo-squelettiques liés à l'âge. 본 발명은 리소좀 ABCA1 억제제를 포함하는 노화성 근골격계 질환의 예방, 개선 또는 치료용 조성물에 관한 것이다. 보다 구체적으로 본 발명의 조성물은 리소좀 ABCA1 억제제를 포함함으로써 세포의 ABCA1이 리소좀으로 운반되는 것을 억제하거나 리소좀내 ABCA1을 억제하여 리소좀 콜레스테롤 축적을 억제 및 노화연관염증인자(SASP) 생성을 억제함에 따라 노화성 염증을 억제하고 노화성 근골격계 질환을 예방, 개선 또는 치료할 수 있다.