ENGINEERED AAV POLYPEPTIDES

The present disclosure provides engineered AAV capsid polypeptides, engineered MAAP polypeptides, and engineered AAP polypeptides as well as recombinant polynucleotides encoding the engineered AAV polypeptides. The present disclosure further provides use of the engineered AAV polypeptides and recomb...

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Hauptverfasser:	SEDIGHI, Faezeh, CHNG, Chinping, KUMAR, Ambuj, SERO, Antoinette, ROHOVIE, Marcus, WONG, Victoria, AKEEFE, Hassibullah, GEBRETSADIK, Kahsay, SCHMITT, Christopher, DEL GRECO, Elizabeth, SILVERMAN, Adam, KRUSE, Nikki, DESAUTEL, Sarah, RIVERA-VELAZQUEZ, Mirella
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present disclosure provides engineered AAV capsid polypeptides, engineered MAAP polypeptides, and engineered AAP polypeptides as well as recombinant polynucleotides encoding the engineered AAV polypeptides. The present disclosure further provides use of the engineered AAV polypeptides and recombinant polynucleotides for producing rAAV viruses or rAAV virions. La présente divulgation concerne des polypeptides de capside d'AAV modifiés, des polypeptides MAAP modifiés et des polypeptides AAP modifiés ainsi que des polynucléotides recombinants codant pour les polypeptides AAV modifiés. La présente divulgation concerne en outre l'utilisation des polypeptides AAV modifiés et des polynucléotides recombinants pour produire des virus rAAV ou des virions rAAV.