HSC-SPECIFIC ANTIBODY CONJUGATED LIPID NANOPARTICLES AND USES THEREOF

Provided are ionizable cationic lipids and lipid nanoparticles for the delivery of nucleic acids to cells (e.g., HSC), and methods of making and using such lipids and targeted lipid. nanoparticles. L'invention concerne des nanoparticules lipidiques et des lipides cationiques ionisables pour l&#...

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Bibliographische Detailangaben
Hauptverfasser:	BOESCH, Austin Wayne, DRUMMOND, Daryl Clark, HOPE, Jacob, BORGES, Christopher
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Provided are ionizable cationic lipids and lipid nanoparticles for the delivery of nucleic acids to cells (e.g., HSC), and methods of making and using such lipids and targeted lipid. nanoparticles. L'invention concerne des nanoparticules lipidiques et des lipides cationiques ionisables pour l'administration d'acides nucléiques à des cellules (par exemple, des cellules souches hématopoïétiques, (CSH)), ainsi que des méthodes de fabrication et d'utilisation de tels lipides et nanoparticules lipidiques ciblées.