TETRACYCLIC DERIVATIVES AS KRAS INHIBITORS

Provided are certain tetracyclic derivatives that inhibit certain K-Ras proteins and are therefore useful for the treatment of cancers mediated by such proteins. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds. L'invention conce...

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Bibliographische Detailangaben
Hauptverfasser:	FU, Jiping, SUN, Yongfeng, ZENG, Haiqiang
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:	Provided are certain tetracyclic derivatives that inhibit certain K-Ras proteins and are therefore useful for the treatment of cancers mediated by such proteins. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds. L'invention concerne certains dérivés tétracycliques qui inhibent certaines protéines K-Ras et sont par conséquent utiles pour le traitement de cancers médiés par de telles protéines. L'invention concerne également des compositions pharmaceutiques contenant de tels composés et des procédés de préparation de tels composés.