SUBSTITUTED 1H-PYRAZOLE-4-CARBOXAMIDES AS SARM1 INHIBITORS

The present invention relates to novel substituted 1H-pyrazole-4-carboxamide compounds as SARM1 inhibitors, to pharmaceutical compositions comprising the compounds and to methods of using the compounds and compositions to treat and prevent pathological conditions involving axonal degeneration. La pr...

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Bibliographische Detailangaben
Hauptverfasser:	DEVRAJ, Rajesh, BOSANAC, Todd, BREARLEY, Andrew Simon, PARROTT, Shelley Anne, HUGHES, Robert Owen
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to novel substituted 1H-pyrazole-4-carboxamide compounds as SARM1 inhibitors, to pharmaceutical compositions comprising the compounds and to methods of using the compounds and compositions to treat and prevent pathological conditions involving axonal degeneration. La présente invention concerne de nouveaux composés 1H-pyrazole-4-carboxamide substitués en tant qu'inhibiteurs de SARM1, des compositions pharmaceutiques comprenant les composés et des méthodes d'utilisation desdits composés et compositions pour traiter et prévenir des états pathologiques impliquant une dégénérescence axonale.