CRYSTALLINE FORMS OF N-[4-[4-(4-MORPHOLINYL)-7H-PYRROLO[2,3-D]PYRIMIDIN-6- YL]PHENYL]-4-[[3(R)-[(L-OXO-2-PROPEN-L-YL)AMINO]-L-PIPERIDINYL]METHYL]-2-PYRIDINECARBOXAMIDE AS A COVALENT INHIBITOR OF MENIN-MLL INTERACTION

Described herein is N-[4-[4-(4-morpholinyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]phenyl]-4-[[3(R)-[(1-oxo-2-propen-1-yl)amino]-1-piperidinyl]methyl]-2-pyridinecarboxamide (Compound A) (Formula I), including crystalline forms, solvates, and pharmaceutically acceptable salts thereof. Also disclosed are pha...

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Bibliographische Detailangaben
Hauptverfasser:	YOU, Mei, PALMER, James T, WONG, Angelina Sau Man, HE, Hongyan, KIRSCHBERG, Thorsten A, LIN, Ming, DING, Junlu, GU, Yuyao, QIU, Yihong, ZHENG, Bo, GAO, Ming, ZHOU, Yanjing, TAN, Heow Meng, LI, Jay, LI, Shuang, PUPPALI, Satish Goud
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:	Described herein is N-[4-[4-(4-morpholinyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]phenyl]-4-[[3(R)-[(1-oxo-2-propen-1-yl)amino]-1-piperidinyl]methyl]-2-pyridinecarboxamide (Compound A) (Formula I), including crystalline forms, solvates, and pharmaceutically acceptable salts thereof. Also disclosed are pharmaceutical compositions or pharmaceutical formulations that include the compound, as well as methods of using the compound, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, diabetes, and inflammatory diseases or conditions. Est divulgué dans la description du N-[4-[4-(4-morpholinyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]phényl]-4-[[3(R)-[(1-oxo-2-propen-1-yl)amino]-1-pipéridinyl]méthyl]-2-pyridinecarboxamide (composé A) (formule I), y compris des formes cristallines, des solvates et des sels pharmaceutiquement acceptables correspondants. Sont également divulguées des compositions pharmaceutiques ou des formulations pharmaceutiques contenant le composé, ainsi que des procédés d'utilisation du composé, seul ou combiné à d'autres agents thérapeutiques, pour traiter des maladies ou affections auto-immunes, des maladies ou affections hétéro-immunes, le cancer, dont le lymphome, le diabète, et des maladies ou affections inflammatoires.