STABILIZED BIOPOLYMER COMPOSITION, THEIR MANUFACTURE AND USE

The present invention relates to the field of stabilized biopolymer compositions, particularly to stabilized biopolymer compositions comprising a liquid mixture, in particular aqueous solution, of at least one biopolymer component and at least one stabilizing surfactant. More specifically, the present invention relates to stabilized biopolymer compositions comprising an ethylene oxide/butylene oxide block copolymer capable to confer to said biopolymer composition superior properties in comparison to the presently known formulations, particularly with regard to aggregation tendency, hemolytic activity and solubility. The invention further relates to said block copolymers, to methods for preparing said stabilized compositions and to the use of said block copolymers for stabilizing an aqueous composition of said biopolymer. The invention further relates said stabilized composition for use in medicine, in particular for diagnostic and/or therapeutic applications. The invention further relates to an essentially dry biopolymer composition, comprising said biopolymer and said block copolymers and to methods for preparing said essentially dry compositions. The invention further relates to said essentially dry biopolymer composition for use in medicine, in particular for diagnostic and/or therapeutic applications. Said compositions may be formulated as pharmaceutical compositions which may be delivered via suitable routes of administration such as via oral, rectal, transmucosal, topical, ophthalmic, otologic, or intestinal administration; parenteral delivery, including intramuscular, subcutaneous, intramedullary injections, as well as intrathecal, direct intraventricular, intravenous, intraperitoneal, intranasal, or intraocular injections, as the case may be. La présente invention concerne le domaine des compositions biopolymères stabilisées, en particulier des compositions biopolymères stabilisées comprenant un mélange liquide, en particulier une solution aqueuse, d'au moins un composant biopolymère et d'au moins un tensioactif stabilisant. Plus précisément, la présente invention concerne des compositions de biopolymère stabilisées comprenant un copolymère séquencé d'oxyde d'éthylène/oxyde de butylène permettant de conférer à ladite composition de biopolymère des propriétés supérieures par rapport aux formulations actuellement connues, en particulier en ce qui concerne la tendance à l'agrégation, l'activité hémolytique et la solubilité. L'invention concerne en out