PROTEOLYSIS TARGETING CHIMERA COMPOUND
The present invention provides a targeted degradation chimera compound targeting protein tyrosine phosphatase, in particular a compound represented by formula (I), or a pharmaceutically acceptable salt, an isotope variant, a tautomer, a stereoisomer, a prodrug, a polymorph, a hydrate or a solvate th...
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| Format: | Patent |
| Sprache: | chi ; eng ; fre |
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| Zusammenfassung: | The present invention provides a targeted degradation chimera compound targeting protein tyrosine phosphatase, in particular a compound represented by formula (I), or a pharmaceutically acceptable salt, an isotope variant, a tautomer, a stereoisomer, a prodrug, a polymorph, a hydrate or a solvate thereof. The present invention also provides a preparation method for the compound, a pharmaceutical composition comprising the compound, and an effect of the compound in prevention and treatment of related diseases, such as hematological tumor or solid tumor diseases.
La présente invention concerne un composé chimère de dégradation ciblée ciblant la protéine tyrosine phosphatase, en particulier un composé représenté par la formule (I), ou un sel pharmaceutiquement acceptable, un variant isotopique, un tautomère, un stéréoisomère, un promédicament, un polymorphe, un hydrate ou un solvate de celui-ci. La présente invention concerne également un procédé de préparation du composé, une composition pharmaceutique comprena |
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