AZACYCLOALKANE COMPOUND AND PHARMACEUTICAL COMPOSITION, AND USE THEREOF

The present application relates to an azacycloalkane compound and a pharmaceutical composition, and a use thereof. The compound has a structural formula as shown in formula (I). The azacycloalkane compound and the pharmaceutical composition thereof provided by the present invention have remarkable R...

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Bibliographische Detailangaben
Hauptverfasser:	DU, Daniel Yunlong, ZHU, Li, ZHANG, Hui, HU, Wei
Format:	Patent
Sprache:	chi ; eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present application relates to an azacycloalkane compound and a pharmaceutical composition, and a use thereof. The compound has a structural formula as shown in formula (I). The azacycloalkane compound and the pharmaceutical composition thereof provided by the present invention have remarkable Rho kinase inhibitory activity, the enzymatic activity and cell activity of the azacycloalkane compound and the pharmaceutical composition thereof are superior to those of existing ROCK inhibitors such as Ripasudil, Netarsudil, and Belumosudil, and thus the azacycloalkane compound and the pharmaceutical composition thereof have great potential for application. La présente demande concerne un composé azacycloalcane, une composition pharmaceutique et une utilisation associées. Le composé a une formule développée telle que représentée dans la formule (I). Le composé azacycloalcane et la composition pharmaceutique de celui-ci selon la présente invention ont une activité inhibitrice remarquable de Rho kinase, l'activité