OXADIAZOLE COMPOUND, AND PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION AND USE THEREOF

Disclosed in the present invention are an oxadiazole compound, and a preparation method therefor, and a pharmaceutical composition and the use thereof. The oxadiazole compound has a structure as shown in formula (I). A stereoisomer, a mesomer, a racemate, a prodrug, a crystal, or a pharmaceutically acceptable salt thereof, or a mixture thereof is further included. The oxadiazole compound has PD-L1 inhibitory activity, can significantly inhibit PD-1/PD-L1 protein-protein interaction, and blocks a PD-1/PD-L1 signal pathway, and therefore can be prepared as an immunomodulator drug for preventing and/or treating tumors, infectious diseases, inflammatory diseases, autoimmune diseases or organ-graft refection. La présente invention concerne un composé oxadiazole, son procédé de préparation, une composition pharmaceutique et une utilisation associées. Le composé oxadiazole a une structure telle que représentée dans la formule (I). L'invention concerne en outre un stéréoisomère, un mésomère, un racémate, un promédica