THERAPEUTIC OLIGONUCLEOTIDE-CONTAINING PHARMACEUTICAL COMPOSITIONS AND DOSING REGIMENS USING THE SAME

Pharmaceutical compositions are disclosed that include a double-stranded RNAi agent that modulates LPA expression or its pharmaceutically acceptable salt thereof in water. Doses and dosing regimens for such RNAi agents also are disclosed that include administering doses from about 4 mg to about 608...

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Bibliographische Detailangaben
Hauptverfasser:	KAUR, Amritpreet, MA, Xiaosu, NI, Wei, GARG, Ashish, KREGE, John Henry, HAW, Helle Linnebjerg
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Pharmaceutical compositions are disclosed that include a double-stranded RNAi agent that modulates LPA expression or its pharmaceutically acceptable salt thereof in water. Doses and dosing regimens for such RNAi agents also are disclosed that include administering doses from about 4 mg to about 608 mg at a frequency of monthly to yearly. L'invention concerne des compositions pharmaceutiques qui comprennent un agent ARNi double brin qui module l'expression de LPA ou son sel pharmaceutiquement acceptable dans l'eau. L'invention concerne également des doses et des régimes posologiques pour de tels agents d'ARNi qui comprennent l'administration de doses d'environ 4 mg à environ 608 mg à une fréquence mensuelle à annuelle.