POLYMORPHS OF THE MALEIC ACID SALT OF LINAPRAZAN GLURATE

The present invention relates to a polymorph of the maleic acid salt of 5-{2-[({8-[(2,6- dimethylbenzyl)amino]-2,3-dimethylimidazo[1,2-a]pyridine-6-yl}carbonyl)-amino]ethoxy}-5- oxopentanoic acid (linaprazan glurate), more specifically Form 1 of the maleic acid salt of linaprazan glurate. The invent...

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Bibliographische Detailangaben
1. Verfasser:	HILLGREN, Mikael
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to a polymorph of the maleic acid salt of 5-{2-[({8-[(2,6- dimethylbenzyl)amino]-2,3-dimethylimidazo[1,2-a]pyridine-6-yl}carbonyl)-amino]ethoxy}-5- oxopentanoic acid (linaprazan glurate), more specifically Form 1 of the maleic acid salt of linaprazan glurate. The invention also relates to pharmaceutical compositions comprising such a polymorph, and to the use of this polymorph in the treatment or prevention of gastrointestinal inflammatory diseases or gastric acid related diseases, in particular erosive gastroesophageal reflux disease (eGERD). La présente invention concerne un polymorphe de sel d'acide maléique de l'acide 5-{2-[({8-[(2,6- diméthylbenzyl)amino]-2,3-diméthylimidazo[1,2-a]pyridine-6-yl}carbonyl)-amino]éthoxy}-5-oxopentanoïque (linaprazan glurate), plus particulièrement la forme 1 du sel d'acide maléique de linaprazan glurate. L'invention concerne également des compositions pharmaceutiques comprenant de tel polymorphe, et l'utilisation de ce polymorphe dans le traitement ou la prévention de maladies inflammatoires gastro-intestinales ou de maladies associées à l'acide gastrique, en particulier le reflux gastro-œsophagien pathologique érosif (eGERD).