PERTUSSIS TOXIN DETOXIFICATION METHOD AND DIPHTHERIA, TETANUS AND ACELLULAR PERTUSSIS COMBINED VACCINE

The present invention provides a pertussis toxin (PT) detoxification method, a detoxified PT antigen prepared by the method, and a diphtheria, tetanus and acellular pertussis combined vaccine. Formaldehyde and glutaraldehyde are used as detoxification agents for a PT antigen, and the detoxification...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	LI, Junqiang, ZHOU, Chaodong, LIAN, Hongyu, CHEN, Liesheng, ZHU, Tao, HUANG, Jian, HAO, Bo
Format:	Patent
Sprache:	chi ; eng ; fre
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention provides a pertussis toxin (PT) detoxification method, a detoxified PT antigen prepared by the method, and a diphtheria, tetanus and acellular pertussis combined vaccine. Formaldehyde and glutaraldehyde are used as detoxification agents for a PT antigen, and the detoxification sequence is as follows: formaldehyde is used for treatment and detoxification first, and then glutaraldehyde is used for detoxification. The diphtheria, tetanus and acellular pertussis combined vaccine adsorbed prepared after detoxification has good immunogenicity and titer, and is low in toxicity, safe, effective and controllable in quality. La présente invention concerne un procédé de détoxification de la toxine pertussique (PT), un antigène PT détoxifié préparé par le procédé, et un vaccin combiné contre la diphtérie, le tétanos et la coqueluche acellulaire. Le formaldéhyde et le glutaraldéhyde sont utilisés en tant qu'agents de détoxification pour un antigène PT, et la séquence de détoxification est la suivante