MINIMAL RESIDUAL DISEASE DETECTION METHOD AND APPARATUS, DEVICE, AND STORAGE MEDIUM

The present application discloses a minimal residual disease detection method and apparatus, a device, and a storage medium. The method is based on differential-depth whole exome/targeted drug sequencing and tissue-blood cell-plasma co-capture technology, as well as a one hundred thousand×ultra-high...

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Hauptverfasser: YU, Jianing, ZHANG, Yaxi, LIU, Yiqian, MA, Lingran, HUANG, Yu, CHEN, Weizhi, SU, Zhencheng, FAN, Rui, DU, Bo
Format: Patent
Sprache:chi ; eng ; fre
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Zusammenfassung:The present application discloses a minimal residual disease detection method and apparatus, a device, and a storage medium. The method is based on differential-depth whole exome/targeted drug sequencing and tissue-blood cell-plasma co-capture technology, as well as a one hundred thousand×ultra-high-depth customized/high-evidence hotspot combined panel sequencing mode, and is a method for evaluating minimal residual disease and tumor evolution/second primary onset in a plasma sample, and the accuracy of recurrence risk prediction after patient treatment is improved within a limited cost range. La présente demande concerne un procédé et un appareil de détection de maladie résiduelle minimale, un dispositif et un support de stockage. Le procédé est basé sur un séquençage d'exome entier/de médicament ciblé par profondeur différentielle et sur une technologie de co-capture de tissu-cellule sanguine-plasma, ainsi que sur un mode de séquençage de panneau combiné de point d'accès à forte indication/très grande profo