INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE, COMPOSITIONS, AND METHODS OF USE

Disclosed are compounds of Formula (I) pharmaceutically acceptable salts thereof are defined here and pharmaceutical compositions thereof and combinations thereof, and methods of using the same as inhibitors of protein tyrosine phosphatases (PTPN2). These compounds are useful in treating cancer and...

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Bibliographische Detailangaben
Hauptverfasser:	MU, Yucheng, PENDRI, Annapurna, CHUPAK, Louis S, LIU, Haibo, POSY, Shoshana L, BRONSON, Joanne Jewett, D'AGOSTINO, Laura Akullian
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Disclosed are compounds of Formula (I) pharmaceutically acceptable salts thereof are defined here and pharmaceutical compositions thereof and combinations thereof, and methods of using the same as inhibitors of protein tyrosine phosphatases (PTPN2). These compounds are useful in treating cancer and diseases susceptible to PTPN2 inhibition. L'invention concerne des composés de formule (I), des sels pharmaceutiquement acceptables de ceux-ci ainsi que des compositions pharmaceutiques de ceux-ci et des combinaisons de ceux-ci, et des procédés d'utilisation de ceux-ci en tant qu'inhibiteurs de protéines tyrosine phosphatases (PTPN2). Ces composés sont utiles dans le traitement du cancer et de maladies sensibles à l'inhibition de PTPN2.