EXTRACELLULAR VESICLE-ENRICHED SECRETOME COMPOSITION DERIVED FROM INDUCED PLURIPOTENT STEM CELL DERIVED-MICROGLIA AND METHODS OF USE THEREOF

The present disclosure provides extracellular vesicle-enriched compositions derived from iPSC-derived microglia. Further provided herein are methods for using the extracellular vesicle-enriched compositions from iPSC-derived microglia in screening assays to discover properties, including therapeutic...

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Bibliographische Detailangaben
Hauptverfasser:	NELSON, Dana, SMITH, Steve, HARMS, Lisa, HAMRICK, Michele, TOMOTOSHI, Kimihiko, BAKSHY, Kiranmayee, CARLSON, Coby, LIVINGSTON, Megan, RENAULT, Nisa, WONG, Jacquelyn
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS TESTING
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Beschreibung
Zusammenfassung:	The present disclosure provides extracellular vesicle-enriched compositions derived from iPSC-derived microglia. Further provided herein are methods for using the extracellular vesicle-enriched compositions from iPSC-derived microglia in screening assays to discover properties, including therapeutic properties. La présente invention concerne des compositions enrichies en vésicules extracellulaires dérivées de la microglie dérivée d'iPSC. L'invention concerne en outre des procédés d'utilisation des compositions enrichies en vésicules extracellulaires à partir de la microglie dérivée d'iPSC dans des dosages de criblage pour découvrir des propriétés, y compris des propriétés thérapeutiques