KDM1A INHIBITORS FOR THE TREATMENT OF DISEASE

Disclosed herein are new compounds and compositions and their application as pharmaceuticals for the treatment of diseases. Methods of inhibition of KDM1A, methods of increasing gamma globin gene expression, and methods to induce differentiation of cancer cells in a human or animal subject are also...

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Bibliographische Detailangaben
Hauptverfasser:	CELATKA, Cassandra, REINHOFF, JR, CLARE, Michael, TAPPER, Amy E, NAMDEV, Nivedita
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Disclosed herein are new compounds and compositions and their application as pharmaceuticals for the treatment of diseases. Methods of inhibition of KDM1A, methods of increasing gamma globin gene expression, and methods to induce differentiation of cancer cells in a human or animal subject are also provided for the treatment of diseases such as acute myelogenous leukemia. L'invention concerne de nouveaux composés et compositions et leur application en tant que produits pharmaceutiques pour le traitement de maladies. L'invention concerne également des procédés d'inhibition de KDM1A, des procédés d'augmentation de l'expression du gène de la gamma globine, et des procédés d'induction de la différenciation de cellules cancéreuses chez un sujet humain ou animal pour le traitement de maladies telles que la leucémie myéloïde aiguë.