INHALATION FORMULATION COMPRISING NANOPARTICLES AND PREPARATION METHOD THEREFOR

The present invention relates to an inhalation formulation comprising nanoparticles and a preparation method therefor, in which pharmacologically active ingredients are included in the nanoparticles, particle sizes are uniform, and biocompatibility is excellent such that the residence time in the lungs is increased, thereby allowing the formulation to be used as a lung-targeted inhalation formulation that can continuously release pharmacologically active ingredients. In addition, to form nanoparticles, by including a biocompatible polymer and/or lipid and a surfactant at an appropriate ratio, the particle size, encapsulation ratio, and zeta potential difference are optimally controlled, so that a uniform particle size distribution can be provided and agglomeration between particles can be prevented. La présente invention concerne une formulation pour inhalation comprenant des nanoparticules et son procédé de préparation, dans laquelle des principes pharmacologiquement actifs sont inclus dans les nanoparticules, les tailles de particule sont uniformes, et la biocompatibilité est excellente de telle sorte que le temps de séjour dans les poumons est augmenté, ce qui permet d'utiliser la formulation en tant que formulation pour inhalation ciblée sur les poumons qui peut libérer en continu des principes pharmacologiquement actifs. De plus, pour former des nanoparticules, en incluant un polymère biocompatible et/ou un lipide et un tensioactif à un rapport approprié, la taille de particule, le rapport d'encapsulation et la différence de potentiel zêta sont régulés de manière optimale, de telle sorte qu'une distribution granulométrique uniforme peut être obtenue et l'agglomération entre les particules peut être évitée. 본 발명은 나노 입자를 포함하는 흡입 제형 및 이의 제조 방법에 관한 것으로, 나노 입자 내 약리 활성 성분을 포함하고 있고, 입도가 균일하며, 생체 적합성이 우수하여 폐 내에서 잔존 시간이 증가되어, 지속적으로 약리 활성 성분을 방출할 수 있는 폐 표적 흡입 제형으로 이용할 수 있다. 또한, 나노 입자를 형성하기 위해, 생체 적합성 고분자 및/또는 지질 및 계면활성제를 적정 비율로 포함함에 따라, 입도, 봉입률 및 제타 전위차를 최적으로 조절하여, 균일한 입도 분포를 가지며, 입자 간의 뭉침 현상을 방지할 수 있다.