METHOD OF MANUFACTURING A HYDROGEL USEFUL FOR PREVENTING POST-SURGICAL ADHESIONS

A method of manufacturing a hydrogel comprises reacting: A) An isocyanate-terminated prepolymer obtained by the reaction of at least: A1) A diisocyanate with a molar mass of 140 to 278 g/mol; A2) A polyalkylene oxide with an ethylene oxide content of ≥ 50 weight-%, calculated from the total weight o...

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Bibliographische Detailangaben
Hauptverfasser:	HECKROTH, Heike, SUETTERLIN, Jan, KORTENBREDE, Lana
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES CHEMISTRY COMPOSITIONS BASED THEREON DISINFECTION, STERILISATION, OR DEODORISATION OF AIR HUMAN NECESSITIES HYGIENE MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONSONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES MEDICAL OR VETERINARY SCIENCE METALLURGY METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL ORGANIC MACROMOLECULAR COMPOUNDS THEIR PREPARATION OR CHEMICAL WORKING-UP
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Beschreibung
Zusammenfassung:	A method of manufacturing a hydrogel comprises reacting: A) An isocyanate-terminated prepolymer obtained by the reaction of at least: A1) A diisocyanate with a molar mass of 140 to 278 g/mol; A2) A polyalkylene oxide with an ethylene oxide content of ≥ 50 weight-%, calculated from the total weight of the polyalkylene oxide; B) A polyamine; C) Water. The polyalkylene oxide A2) and/or the polyamine B) further comprise ester groups and the average OH functionality of polyalkylene oxide A2) is greater than 2 and/or the average combined primary and secondary amine functionality of polyamine B ) is greater than 2. Un procédé de fabrication d'un hydrogel comprend la réaction : A) d'un prépolymère à terminaison isocyanate obtenu par la réaction d'au moins : A1) un diisocyanate ayant une masse molaire de 140 à 278 g/mol ; A2) un oxyde de polyalkylène ayant une teneur en oxyde d'éthylène ≥ 50 % en poids, calculée à partir du poids total de l'oxyde de polyalkylène ; B) d'une polyamine ; C) d'eau. L'oxyde de polyalkylène A2) et/ou la polyamine B) comprennent en outre des groupes ester et la fonctionnalité OH moyenne de l'oxyde de polyalkylène A2) est supérieure à 2 et/ou la fonctionnalité amine primaire et secondaire combinée moyenne de la polyamine B) est supérieure à 2.